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Albert Pharma
Pentoxifylline
Vasoactive Agent
Action And Clinical Pharmacology: Pentoxifylline is a xanthine derivative. It belongs to a group of vasoactive drugs which improve peripheral blood flow and thus enhance peripheral tissue oxygenation. The mechanism by which pentoxifylline achieves this effect has not been determined, but it is likely that the following factors are involved: Pentoxifylline, as other xanthine derivatives, relaxes certain smooth muscles including those of the peripheral vessels, thus causing vasodilatation or preventing spasm. This action, however, may have a limited role in patients with chronic obstructive arterial disease when peripheral vessels are already maximally dilated.
Pentoxifylline improves flexibility of red blood cells. This increase in the flexibility of red blood cells probably contributes to the improvement of the ability of blood to flow through peripheral vessels (hemorheologic action). This property was seen during in vitro and in vivo experiments with pentoxifylline but the correlation between it and the clinical improvement of patients with peripheral vascular diseases has not been determined.
Pentoxifylline promotes platelet deaggregation.
Improvement of red blood cell flexibility and platelet deaggregation contribute to the decrease in blood viscosity
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