أهلا sweetlife
بالنسبة لصاحب البحث هو طالب الماجستير حسان الخوري و الأستاذ المشرف على البحث هو الدكتور محمد معروف
واليك بعض الدراسات والمراجع التي تدعم هذا البحث :
Danilo C. Miguel, Jenicer K.U. Yokoyama-Yasunaka1, Walter K. Andreoli, Silvia R. B. Uliana and Renato A. Mortara:
Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes.
Journal of Antimicrobial Chemotherapy, 10(4): 1-9, 2007.
Danilo C. Miguel, Jenicer K.U. Yokoyama-Yasunaka and Silvia R.B. Uliana.
Tamoxifen is Effective in the Treatment of Leishmania amazonensis Infections in Mice. Public Library of Science Neglected Tropical Diseases, 2(6):1-5, 2008.
Beggs WH.
Drug protonation and pH in relation to the lethal action of tamoxifen on Candida albicans.
J Antimicrob Chemother, 37: 802-841, 1996.
Marchesini N. and Docampo R.
A plasma membrane P-typeH+ -ATPase regulates intracellular pH in Leishmania mexicana amazonensis.
Mol Biochem Parasitol; 119: 225-236, 2002.
Wang ZE; Reiner SL; Zhengs, Dalton DK. and Locksley KM.
CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.
J Exp med; 179(4): 1367-1371, 1994.
Swihart K; Fruth U; Messmer N; Hug K; Behin R; Huang S; Del Giudice G. Aguet M. and Louis J.A.
Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4 T cell response.
J. Exp, Med. 181, 961-971, 1995.
Loo SA; Lesoon-Wood LA. and Cooney RV.
Effects of tamoxifen on nitric oxide synthesis and neoplastic transformation in C3H 10T1/2 fibroblasts.
Cancer Lett; 122, 67-75, 1998
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