رد مشاركة : مشروع ترجمة موسوعة التكنولوجيا الصيدلية الجماعي...
مر حبا
الله يعطيكم العافية جميعا وانشاء الله بدوم هالتعاون بين الجميع
أول شي بدي طمنكم انو تقريباً خلصت قسمي بس باقي شوي مع بعض الرتوش
بس في كم مصطلح ما عم اعرف شو اعتمدهن بالنهاية ياريت تساعدوني فيهن و تعرضوهن على الدكاترة
رح حطت الفقرة مع رقم الصفحة
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In this case, monolithic devices (tablets) made from mucoadhesive hydrogels were evaluated.[8] Ocular and vaginal applications (for local or systemic absorption) of mucoadhesive hydrogels were also investigated.
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Mucins can be divided into two classes, membrane bound and secretory forms. Membrane-bound mucins are attached to cell surfaces and may affect immune responses or inflammation.
It has been suggested that the high expression of cell-surface mucins, such as sialomucin MUC1, may result in cell–cell and cell–matrix interactions
Important constituents in the mucus include growth factors and trefoil peptides, both secreted by the specialized cells located next to ulcerated mucosal tissue.
Attempts were also made to estimate the rate of turnover of the mucus gel. Lehr et al.[13] measured
the amount of mucus produced per time unit, using an in situ perfused intestinal loop model in the rat
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When two materials come into contact with each other, electron transfer occurs, causing the formation of a double layer of electrical charge at the bioadhesive–biological interface.
The adsorption theory states that the bioadhesive bond formed between an adhesive substrate and tissue
or mucosae is due to van der Waals interactions, hydrogen bonds, and related forces. Alternatively,
when mucus or saliva are interacting with a solid dosage form, the molecules of the liquid are adsorbed on the solid surface. This is anexothermic process.
The intimate contact of the two substrates is essential for diffusion to occur; that is, the driving force for the interdiffusion is the concentration gradient across the interface.
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Mikos and Peppas[19] described the flow channel to measure the bioadhesion of polymer microparticles on mucin gels. Later Lehr et al.[20] used an in situ loop model in the rat for the investigation of mucoadhesive microspheres (Fig. 3).
Rheology measurements were used by Mortazavi Carpenter, and Smart[25,26] to investigate mucus–
Carbopol 934P interactions at different pH values and the role of water movement in mucoadhesion. Similar rheological techniques were applied for studying four different types of polymers
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Rossi et al.[29] evaluated rheologically mucins of different origin with polyacrylic acid and sodium carboxymethyl cellulose. The same group also reported a novel rheological approach based on a stationary viscoelastic test (creep test) to describe the interaction between mucoadhesive polymers and mucins.[
Jabbari, Wisniewski, and Peppas[32] used attenuated total-reflection infrared spectroscopy to investigate the chain interpenetration of polyacrylic acid in the mucin interface , Other techniques used for studying molecular interactions between polymers and mucus include ultracentrifugation, surface plasmon resonance, and electromagnetic transduction
for the visualization of mucoadhesive interfaces. Transmission electron microscopy in combination with near-field Fourier transform infrared microscopy (FTIRhas been shown to be suitable for investigating the adhesion-promoting effect of polyethyleneglycol added in a hydrogel.[.
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في شغلة كمان أنا ماعم أعرف شو قصدكن بالتنضيد
وشو صار بالجدول
إعلان هام لطلاب كلية الصيدلة ( تم تعديل البرنامج النهائي لامتحان ف2 )
مـنـتـدى تـرجـمــة وتـدقـيـق أقــســام الـمـوســـوعـة 
للتواصل مع الهيئة الإدارية في كلية الصيدلة اضغط هنا 
مشروع ترجمة موسوعة التكنولوجيا الصيدلية الجماعي...
